Nicotine Rage: A Guide to Quitting Chewing Tobacco

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Nicotine levels in the blood rise quickly after smoking, with arterial blood levels exceeding venous levels in the first few minutes figure Because nicotine is a weak base and is ionized at acid pH, there is little absorption of nicotine through the membranes of the mouth from the acidic smoke of blond light-colored tobacco. However, the smoke of pipes, cigars, and dark tobacco is more alkaline, so nicotine is absorbed through the mouth from these products. When oral snuff or chewing tobacco is used, nicotine is also absorbed through the mouth.

Nicotine from oral snuff or chewing tobacco is absorbed more slowly than from cigarette smoke; peak plasma concentrations of nicotine in venous blood are similar. Shaded bars show the period of tobacco or nicotine use. Vertical bars indicate ranges.